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產(chǎn)品規格
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BN41831R-50ul
50ul
￥1486.00
交叉反應：Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Rabbit) 推薦應用：Flow-Cyt,ELISA
BN41831R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Rabbit) 推薦應用：Flow-Cyt,ELISA
BN41831R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Rabbit) 推薦應用：Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱(chēng) | CD44 |
| 中文名稱(chēng) | CD44抗體 |
| 別 名 | Homing Cell Adhesion Molecule; Epican; Heparan sulfate proteoglycan; Hyaluronate receptor; Antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen homing function and Indian blood group system; CD44 molecule; CD44 molecule Indian blood group; CD44R; CDw44; CDW44 antigen; Chondroitin sulfate proteoglycan 8; CSPG8; ECMR III; ECMRIII; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; Hematopoietic cell E and L selectin ligand; Hermes antigen; Homing function and Indian blood group system; HUTCH I; IN ; INLU related p80 glycoprotein; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH I; MUTCHI; PGP 1; Phagocytic glycoprotein I; CD44_RAT. |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Chicken, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 Flow-Cyt=1μg/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat CD44v6:325-429/429 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes. CD44R, and in particular CD44v6 containing isoforms, may be involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to sites of inflammation. CD44v6 containing isoforms may be involved in tumor metastasis. The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]. Function: Main cell surface receptor for hyaluronate. Adhesion to ucosal high endothelial venule and to types I and VI collagen. robably involved in matrix adhesion, lymphocyte activation and ymph node homing. Subunit: Interacts with PKN2. Subcellular Location: Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. Post-translational modifications: N-glycosylated. O-glycosylated; contains chondroitin sulfate glycans which an be more or less sulfated. Phosphorylated; activation of PKC results in the ephosphorylation of Ser-467 (constitutive phosphorylation site), nd the phosphorylation of Ser-433. Similarity: Contains 1 Link domain. SWISS: P16070 Gene ID: 960 Database links: Entrez Gene: 960 Human Entrez Gene: 12505 Mouse Omim: 107269 Human SwissProt: P16070 Human SwissProt: P15379 Mouse Unigene: 502328 Human Unigene: 423621 Mouse Unigene: 1120 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD44V6參與細胞與細胞、細胞與基質(zhì)問(wèn)的黏附,與細胞骨架蛋白結合，并與細胞的遷移運動(dòng)有關(guān),與腫瘤細胞的浸潤與轉移有關(guān)。 |
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